Research Use Only — Not for Human Consumption. This compound is sold exclusively for in vitro laboratory research by qualified professionals.
AICAR
AICAR — 5-Aminoimidazole-4-carboxamide Ribonucleoside (50 mg)
AICAR (acadesine) is a nucleoside analogue that is phosphorylated intracellularly to AICAR-monophosphate (ZMP), an AMP mimetic that directly activates AMPK. AMPK activation by AICAR stimulates glucose uptake in skeletal muscle via GLUT4 translocation, activates the PGC-1α/TFAM axis to drive mitochondrial biogenesis, and shifts cellular metabolism toward fatty acid oxidation. It serves as the gold-standard pharmacological AMPK activator in research settings. For research use only — not for human consumption.
Third-Party Tested. Every Lot.
Every batch of AICAR undergoes independent HPLC and mass spectrometry analysis through an accredited third-party laboratory before it is released for sale. No exceptions. No internal-only certificates.
RP-HPLC Analysis
Every lot measured by reverse-phase HPLC. AICAR consistently achieves 99.5%+ purity across batches.
ESI Mass Spec
Electrospray ionization mass spectrometry confirms exact molecular weight and rules out structural isomers or impurities.
Lot-Specific CoA
Your Certificate of Analysis references your exact lot number with actual chromatogram data — not a generic template.
Theoretical Research Analysis
All research information below reflects published preclinical literature only. This product is not for human use, consumption, or clinical application of any kind.
AICAR is the most widely used pharmacological AMPK activator and has contributed enormously to understanding the AMPK signaling network. Its use as an exercise mimetic tool has been particularly impactful in studies examining skeletal muscle metabolic adaptation.
Sequence Information
Amino acid sequence:
N/A — nucleoside analogueMolecular Formula
C₉H₁₄N₄O₈P
Molecular Weight
338.21 g/mol
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